An uncommon presentation of Progressive Supranuclear Palsy diagnosed on DaT scan

An Uncommon Presentation of Progressive Supranuclear Palsy Diagnosed on DaT Scan

Diagnosis of Parkinson's disease can be difficult in presence of atypical symptoms and signs. While the commonest reason of parkinsonism is idiopathic Parkinson's disease (PD), other disease entities that can mimic PD should be considered in the light of clinical history and examination findings. However, still some diagnostic dilemmas may exist which may need special investigative modalities. ...

CT scan in progressive supranuclear palsy.

Familial progressive supranuclear palsy.

A progressive extrapyramidal syndrome and dementia occurred in three members of one family. The age of onset was in the seventh decade and the affected individuals showed many of the clinical features of progressive supranuclear palsy (PSP). Necropsy of one individual revealed the neuropathological features of PSP. We propose that this family has a familial form of PSP and review the evidence i...

Progressive Supranuclear Palsy (PSP)

Introduction: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disorder producing characteristic eye movement abnormalities in the classic presentation. The disease pathologically is marked by accumulation of abnormal tau proteins. There are useful MRI features, however the diagnosis remains clinical in the majority of cases, and no objective diagnostic test exists. Treatment at...

Progressive supranuclear palsy.

This review concentrates on the molecular pathology of the protein tau, including its expression in various regions of the brain. The role of post-translational modifications in fibrillogenesis is also discussed, particularly hyperphosphorylation and glycation. However, the initiating event that causes aberrant tau processing remains unclear.